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Abstract

MICRODETERMINATION OF ENTECAVIR DRUG IN ITS PHARMACEUTICALS FORMS AND IN BIOLOGICAL FLUIDS USING ANODIC VOLTAMMETRY

*H.M. Elqudaby, H.A.M. Hendawy1, M.A. Zayed

ABSTRACT

Entecavir (ETV) drug is oxidized at the glassy carbon electrode. Cyclic voltammetry (CV) showed one well- defined oxidation wave. The anodic peak was detected at + 1.07V in a Britton- Robinson buffer at pH 8.0. The oxidation process was found to be irreversible and exhibited diffusion controlled process. The mechanism of the oxidation process was discussed depending upon the number of involved electrons. According to the linear relation between the peak current and the concentration in both differential pulse voltammetry (DPV) and square wave voltammetry (SWV) methods; they were used for ETV quantitative determination in raw material, pharmaceutical dosage form and biological fluids. These two voltammetric techniques were used for the determination of ETV in Britton- Robinson buffer; which allows its quantitation over the range of 2.2 to 32.4 μM and 1.5 to 44.6 μM in supporting electrolyte for DPV and SWV, respectively. The linear response was obtained in the range of 3.9-23.5 and 3.5-27.5 μM for spiked urine sample and 4.7- 21.3 and 3.1-28.0μM for serum sample using DPV and SWV, respectively. The repeatability and reproducibility of the methods for all media (supporting electrolyte, urine and serum samples) were detected. The proposed techniques were successfully applied for the assay of the cited drug in tablets without interference from excipients. No electro active interference from endogenous substances was found in the biological fluids.

Keywords: Entecavir drug- Cyclic voltammetry- Deferential pulse voltammetry- Square wave Voltammetry- Quantification.


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