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Abstract

EFFECT OF METHANOLIC EXTRACT OF ANANAS COMOSUS LEAVES ON GLUCOSE TOLERANCE AND ACETIC ACID-INDUCED PAIN IN SWISS ALBINO MICE

M.M. Faisal, Fairuj Maliha Mhazabin Hossa, Shahnaz Rahman, A.B.M. AnwarulBashar, Shahadat Hossan, Mohammed Rahmatullah1

ABSTRACT

In oral glucose tolerance test (OGTT), methanol extract of Ananas comosus leaves, when administered orally to glucose-loaded Swiss albino mice at doses of 50, 100, 200 and 400 mg/kg body weight led to dose-dependent reductions in blood glucose levels. At these doses, the percent reductions in blood glucose levels were, respectively, 6.5, 20.2, 30.5, and 46.9% compared to control animals. A standard ant hyperglycemic drug, glibenclamide, when administered at a dose of 10 mg/kg body weight reduced blood glucose levels by 47.3%. The extract at the afore-mentioned four doses, also dose-dependently reduced acetic acid-induced abdominal constrictions in mice by 29.6, 37.0, 44.4, and 48.1%, respectively. A standard analgesic drug, aspirin, when administered at doses of 200 and 400 mg/kg reduced the number of abdominal constrictions, respectively, by 44.4 and 55.6%. Preliminary phytochemical screening showed presence of alkaloids, flavonoids, saponins and tannins in the extract, which components can be responsible for the observed blood glucose lowering and analgesic effects.

Keywords: Ananas comosus, OGTT, antihyperglycemic, analgesic.


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