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Abstract

ANTI-DIABETIC, ANTI-OXIDANT ACTIVITIES OF ETHANOLIC PLANT EXTRACT OF SALICORNIA BRACHIATA ROXB. IN STREPTOZOTOCIN INDUCED DIABETIC RATS.

G.V. Pavan Kumar*, B.Pooja, Dr. D. Srinivasa Rao

ABSTRACT

Salicornia species traditionally used as food material commonly called as glasswort. The aim of the present investigation was to evaluate the antidiabetic, Antioxidant activity of ethanolic extract taken from salicornia brachiata Roxb (Chenopodiaceae). Acute toxicity study and oral glucose test of the extract was performed. Diabetes was induced in rat by single intra-peritoneal injection of streptozotocin (55 mg/kg).The rats were divided into following groups: Group I – normal control,Group II (Vehicle) – diabetic control, Group III (STZ-toxic) – salicornia extract I (100 mg/kg, p.o.), Group IV – salicornia extract II (250 mg/kg, p.o.), Group V – salicornia extract III (500 mg/kg, p.o.), Group VI – glibenclamide (10 mg/kg, p.o.). Body weight of each rat in the different groups was recorded daily. Biochemical and antioxidant parameters were determined on day 28.Ethanolic extract of salicornia brachiata did not show any acute toxicity up-to the dose of 2000 mg/kg and shown better glucose utilization in oral glucose tolerance test. orally treatment of different doses of extractdecreased the level of serum glucose, glycated hemoglobin, glucose-6-phosphatase, fructose-1-6-bis phosphate andincreased the level of plasma insulin, hexokinase,decreased liver malondialdehyde but increased thelevel of superoxide dismutase, catalase and glutathione peroxidase. In oral glucose tolerance test observed increased utilization of glucose. Streptozotocin induced diabetes group rats treated with different doses of salicornia brachiata plant extract and glibenclamide significantly increased the body weight.

Keywords: salicornia brachiata, Streptozotocin, Antidiabetic, Antioxidant, Glibenclamide.


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