WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

EFFECT OF PHYSOSTIGMINE ON CARDIOTONIC ACTIVITY OF PAROTOID GLAND SECRETION OF BUFO MELANOSTICTUS (SCHNEIDER) ON ISOLATED HEART OF FROG

Raju Neerati , Ankaiah Meesala, Samatha Talari , Prasad Neerati  andVenkaiah Yanamala *

ABSTRACT

The present investigation was carried out to study the cardiotonic activity of parotoid gland secretion of common Indian Toad Bufo melanostictus on isolated perfused frog heart (Rana tigrina). The cardiotonic activity of parotoid gland secretion of B. melanostictus in normal as well as when induced with physostigmine (eserine) (an organophosphate) was studied. The cardiotonic activity was studied through Syme’s technique; digoxin and propranolol were used as standard drug and β-blocker respectively to characterize the effects on the receptors. The isolated perfused and hypodynamic heart of frog showed a dose dependent positive ionotropic effects. Cardiac stimulant activities were exhibited by the parotoid gland secretion on frog’s heart. Propranolol was unable to block the effect of physostigmine on toad parotoid gland secretion.Thus, the present investigation reports that the parotoid gland secretion increased the force of contraction, heart beat and cardiac output in perfused frog’s heart, whereas, there was no change on hypodynamic heart, indicating that there may be existence of two components, one with β– receptor stimulating activity and other acting directly on the frog’s heart (independent of β1- adrenoreceptors).

Keywords: Bufo melanostictus, Rana tigrina, Cardiotonic activity, Parotoid gland secretion, Physostigmine.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More