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Abstract

DEVELOPMENT AND EVALUATION OF PARACETAMOL AND METOCLOPRAMIDE HYDROCHLORIDE CHEWABLE TABLETS

Dhruba Sankar Goswami*, Deepak Kumar

ABSTRACT

The present study was aimed to developed and evaluate chewable tablets of Paracetamol and Metoclopramide hydrochloride. Paracetamol and Metoclopramide hydrochloride is an oral fixed dose combination for the preparation of chewable tablets used to treat the symptoms of migraine as it comply with physicochemical properties require to improve the effectiveness of therapeutic agent, better bioavailability, improved patient acceptance (especially pediatrics) through pleasant taste, patient convenience; need no water for swallowing, fasten the absorption of drug and for rapid onset of action.The investigation was carried out to study the effect of different proportion of Aerosil, cros carmellose sodium, cross povidone and neem gum. Maize starch was used as binding agent. Tartrazine was used as coloring agent. Aspartame and Vanilla flavor were used as sweetening agent and flavoring agent respectively. Several physicochemical parameters like thickness, diameter, hardness, %weight variation, %loss in weight, drug content, disintegration time, in vitro dissolution studies, kinetics of drug release and stability study for all the formulations were studied and were found within the acceptance limits. Formulation F10 containing neem gum (1%) showed best cumulative drug release for Paracetamol 99.550% and for Metoclopramide hydrochloride 98.587% and disintegration time of 40±0.03 secs, emerging as best formulation.

Keywords: Paracetamol, Metoclopramide hydrochloride, Neem gum.


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