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Abstract

ANTIDIABETIC EFFICACY OF MOLLUGO OPPOSITIFOLIA LINN. EXTRACT- AN ANIMAL MODEL STUDY.

Dr. S. Gopinathan* and Ms. S. Subha

ABSTRACT

Diabetes Mellitus is a metabolic syndrome characterized by hyperglycemia resulting in complications affecting the nerves, kidneys, eyes and micro and macrovascular structures. This metabolic disease causes disturbance in carbohydrate, protein and fat metabolisms and primarily due to the lack of insulin secretion and/or resistance to insulin. Diabetes and its prevalence is growing alarmingly due to the aging, urbanization, sedentary food habits, obesity and lack of physical activity. A wide number of traditional medicinal plants are used to treat diabetes mellitus. There are more than 400 plant species which have scientifically proved for their antidiabetic activity. Objective: The present study was aimed to evaluate the antidiabetic potential of Mollugo oppositifolia extract on alloxan induced diabetic rats and compare their efficacy with the standard drug, Glibenclamide. Experimental design: An animal model study was carried out by using albino Wistar rats. The rats were divided into four groups Group I: Normal healthy control; Group II: Disease control-alloxan (150mg/kgbw) induced diabetic rats. Group III: Diabetes induced rats treated with Mollugo oppositifolia extract (400 mg/kg-bw); Group IV; Drug control animals-diabetes induced rats treated with Glibenclamide (10 mg/kg-bw). After the experimental period of 35 days, the blood and the liver tissue samples were collected and analyzed. Results obtained: Administration of alloxan induced diabetes in rats and showed a significant alterations in (1) biochemical parameters such as blood glucose, serum insulin, glycosylated haemoglobin, serum protein, liver tissue protein, serum urea, serum creatinine, liver glycogen, (2) Glycogen metabolizing enzymes: liver glucokinase, glycogen synthase, glycogen phosphorylase, liver glucose-6- phosphatase, liver glucose-6-phosphate dehydrogenase, (3) Lipid profiles: total lipids, cholesterol, triglycerides, phospholipids, LDL cholesterol, VLDL cholesterol, HDL cholesterol in serum, (4) Liver marker enzymes: serum aspartate aminotransaminase (AST), serum alanine aminotransaminase (ALT), alkaline phosphatase (ALP), (5) Biomarker antioxidants: reduced glutathione and lipid peroxidation and (6) Antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Treatment with plant extract normalized the adverse effects of diabetic condition. Conclusion: Treatment of diabetic rats with Mollugo oppositifolia extract brought back the normalization in all the parameters investigated, which indicate the antihyperglycemic and antidiabetic efficacy of Mollugo oppositifolia extract. The efficacy was comparable with the standard drug, Glibenclamide. In most of the parameters the performance of plant extract was better than the standard drug.

Keywords: Antidiabetic activity, Mollugo oppositifolia extract, Glibenclamide, biochemical parameters.


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