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Abstract

ACUTE AND SUBACUTE TOXICITY STUDY ON AMIRTHA SANJEEVI KULIGAI

D.P. Sangeetha*, V.Banumathi, S. Jayasree

ABSTRACT

Single and polyherbal preparations are being traditionally used in Indian system of medicine especially in siddha medicine. Mostly herbal preparations have less side effects so it is suitable for paediatric use. Amirtha Sanjeevi Kuligai(ASK) is prepared as per classical text book of Balavagadam for respiratory problem in paediatric age group. Before conducting clinical trial, preclinical study should be undergone as per WHO guidelines. The clinical trial has been approved by IEC (IEC.NO - GSMC-CH/1/2013/016). The present preclinical study aim is to carry out safety and toxicity of ASK (IAEC. NO: XXXIX/13/CLBMCP/2013/ dated 29.6.2013). Adult both sex of swiss albino rats weighing 220- 250 gm were used. Acute and Sub-acute toxicity were carried out as per OECD guidelines 423 and 407. Hematological parameters, biochemical parameters, histo-pathological study were performed for all animals. The study concludes that on oral administration of 400 mg/kg of body weight of ASK to swiss albino rats, there was no characteristic clinical sign of toxicity or mortality observed.

Keywords: Amirtha Sanjeevi Kuligai, Toxicity, Respiratory disease, and oral.


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