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Abstract

ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITIES OF THE ETHANOLIC EXTRACT OF THE LEAVES OF DIOSPYROS PILOSANTHERA BLANCO (FAMILY EBENACEAE) IN DIETHYLNITROSOAMINE-INDUCED RAT LIVER TOXICITY

Mayrose. Quezon* and Dr. Mafel C. Ysrael, 

ABSTRACT

Liver cancer is among the leading causes of death worldwide. Diospyros species has been reported to have pharmacological applications arising from its extensive folkloric uses. The claims include antioxidant and anticancer properties. This study was carried out to investigate the antioxidant and hepatoprotective properties of D. pilosanthera, an endemic Philippine plant, in Diethylnitrosoamineinduced rat liver toxicity. Hepatoprotective property of the extract was evaluated against Diethylnitrosoamine (DENA) induced liver toxicity in rats. Rats were pre-administered orally with the ethanolic extract (200, 500 and 1000 mg/kg BW) and sillymarin 125 mg/kg BW for fifteen days prior to a single dose of DENA (50 mg/kg BW; p.o.). Invivo biochemical parameters like catalase, glutathione, alanineaminotranferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) were evaluated to determine the antioxidant and hepatoprotective activities of Diospyros pilosanthera. Histopathological examination of the liver tissues of the rats induced with DENA was also done. Evaluation of the hepatoprotective property of the extract revealed that a dose of 1000 mg/kg possessed significant hepatoprotective activity comparable with sillymarin. Treatment with the extract markedly obviated increases in ALT, AST and ALP while averting significant decreases in reduced glutathione and catalase enzyme levels. Histopathological changes such as centrilobular necrosis, extensive hepatocyte swelling and sinusoidal congestion with red blood cells were averted by extract administration. Phytochemical analysis showed the presence of alkaloids, flavonoids, tannins, glycosides, triterpenes and phenolic compounds. HPLC showed the probable presence of rutin that could be responsible for the tested pharmacological properties. Results of the studies indicate that the ethanolic extract exhibited significant antioxidant and hepatoprotective activities.

Keywords: Hepatoprotective, carcinogenesis, phytomedicine, Diospyros pilosanthera.


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