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Abstract

ENHANCING SOLUBILITY AND DISSOLUTION OF ITRACONAZOLE BY SPRAY DRYING USING PLURONIC F-68

Mudit Dixit*, Parthasarthi Keshavarao Kulkarni and R Narayana Charyulu

ABSTRACT

Itraconazole, an anti-fungal drug, exhibits poor water solubility, dissolution and flow properties. Thus, the aim of the present study was to improve the solubility and dissolution rate of itraconazole by preparing microspheres by spray drying technique. Microspheres containing different ratio of Itraconazole and Pluronic F-68 were produced by spray drying using dichloromethane as solvent to enhance solubility and dissolution rate. The prepared formulations containing different ratio of drug and polymer were evaluated for in vitro dissolution and solubility. The prepared formulations were characterized by scanning electron microscopy (SEM), differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR). Dissolution profile of the spray dried microspheres was compared with its physical mixture and pure sample. Spray dried microspheres exhibited decreased crystallinity and the solubility and dissolution of the microspheres containing different ratio of drug and pluronic F-68 were significant improved compared with its physical mixture and pure sample of Itraconazole. Dissolution of microspheres containing 8:2 w/w (SD 4) showed higher % release i.e. 98 % in 40 min compare to other prepared ratio formulation. Consequently, From the above result it can be conclude that spray dried microspheres of itraconazole is a useful technique to improve the solubility and dissolution of poorly water soluble drug like itraconazole.

Keywords: Spray drying, Itraconazole, Pluronic F-68, microspheres, Solubility, dissolution.


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