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Abstract

A REVIEW ON FORMULATION APPROACH TO ENHANCE ORAL BIOAVAILABILITY OF POORLY SOLUBLE DRUGS BY SELF EMULSIFYING DRUG DELIVERY SYSTEM

*Harendra Prasad, Amit Kumar Batra

ABSTRACT

Most of the drugs which are recently discovered are poorly water soluble and the oral delivery of these drugs have become a major problem. Drugs of Class II or IV, as per biopharmaceutical classification system (BCS) exhibit poor aqueous solubility. The oral delivery of these drugs are affected by low bioavailability, erratic absorption, inter and intra subject variability and lack of dose solubility. Since last couple of years Self-emulsifying drug delivery systems are becoming important tool in novel drug delivery. It is very useful in solving problems such as low bioavailability issues associated with poorly water soluble drugs. The bioavailability of lipophilic drugs (BCS-II and IV) can be enhanced by these systems. SEDDS is released in the lumen of the gastrointestinal tract (GIT) after administration and with the aid of GI fluid a fine emulsion (micro-/nano-emulsion) is formed. The increased surface area and amphoteric nature of SEDDS lead to increase in bioavailability. In this review we present a report on the formulation, characterization and dosage forms and applications of self-emulsifying formulations, with examples of currently marketed preparations.

Keywords: Self emulsifying drug delivery system, Solubility, Bioavailability, Absorption.


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