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Abstract

N-(3-TRIFLUOROMETHYLBENZOYL)-N PHENYLUREA, A NOVEL COMPOUND OF THE CENTRAL NERVOUS SYSTEM DEPRESSANT

*Bambang Tri Purwanto

ABSTRACT

The development of drug molecules which have a spesific activity of pharmacological effect to become the new molecul drug is a challenge in this decade. The new compound which have a spesific action is the need and very necessary. [12] The method for having the new compound is doing by the synthesis from some reactans and the very important step is the proccess. The presence of the compound which have the activity as the central nervous system (CNS) depressant needed to be developed, that is a new challenge and felt more further considering the side effects that drugs have. [4, 7] Urea is a chemical compound that is very well known in the world and in Indonesia, this compound has been able to be produced by the chemical industry. The use of urea compounds in the world and also in Indonesia was limited as a plants fertilizer; it turns out on further development of one of the urea derivative compounds that have pharmacological activity as a central nervous system depressant drug, namely bromisoval. The use of this compound as a depressant of the central nervous system when a barbiturate derivative is no longer effective as a depressant of the central nervous system. [5, 6] The synthesis method used to make urea derivative compounds mentioned above are using the Schotten Baumann method which is has reaction principle between the amine group with the carbonyl group to form a carbamide compound. [8, 17] urwanto B.T, 1991, have successfully synthesize new compounds N-bromobenzoylampicillin having an antibacterial activity by Shotten-Bauman method.[2] Purwanto B.T.,2011, have successfully synthesize new compounds N-benzoyl-N'phenylurea having a CNS depressant activity by Shotten-Bauman method. The development of the N-benzoyl-N'phenylurea derivative compounds is predicted could increase the CNS activity depressant. [3] The depressant activity test of the central nervous system implemented by the Barbituric Sleeping Time (BST) method which consists of two steps, first the timing of peak activity and second is the potentiation test of the compound.

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