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Abstract

ANTIOXIDANT EFFECT OF AJUGA IVA (L) AQUEOUS EXTRACT IN MERCURIC CHLORIDE INDUCED OXIDATIVE STRESS IN RATS

Ahlem Bahi, Youcef Necib*, Soumia Djemai-Zoughlache, Ahlem Bahi, SakinaZerizer , and Cherif Abdennour 

ABSTRACT

The present study was undertaken, to evaluate the protective effect of Aquaous extract of Ajuga Iva against mercuric chloride induced oxidative stress in experimental rats. Female Albinos Wistar rats randomly divided into four groups, were the first was served as a control, whereas the remaining groups respectively treated with: Ajuga Iva (200mg/ kg b.w; by gavage), mercuric chloride (1 mg/kg body weight i.p) and combination of Ajuga Iva and HgCl2. Change in liver enzyme activities, thiobarbituric acid reactive substances (TBARS) level, antioxidants and reduced glutathione (GSH) contents were determined after 10 days experimental period. Exposure of rats to mercuric chloride caused a significant increase the lipid peroxidation level along with corresponding decrease in the reduced glutathione and various antioxidant enzymes in liver. And increase in serum: glucose and bilirubin levels, APL and transaminases activities. Furthermore, treatment with mercuric chloride caused a marked elevation of liver weight and decreased body weight. Supplementation of Aquaous extract Ajuga Iva resulted in decreased of lipid peroxidation level and in the serum: glucose and billirubin levels and AST, ALT and APL activities were decreased along with increase in liver GSH level. The activities of antioxidants enzymes: glutathione peroxidase (GSH-Px) and glutathione –Stransferase (GST) were also concomitantly restored to near normal level by Aquaous extract of Ajuga Iva supplementation to mercuric chloride intoxicated rats. Liver histological studies have confirmed the changes observed in biochemical parameters and proved the beneficial role of Aquaous extract of Ajuga Iva. The results clearly demonstrate that Aquaous extract of Ajuga Iva treatment augments the antioxidants defense mechanism in mercuric chloride induced toxicity and provides evidence that it may have a therapeutic role in free radical mediated diseases.

Keywords: Antioxidant enzymes, Ajuga Iva , Mercury, Oxidative stress, female Rat


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