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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE TABLETS OF ACECLOFENAC

Pankaj Bhateja1, *Pankaj Kumar2, Surya Prakash Gautam1, Hitesh1, Sunny Dogra1, Nitesh Dogra1

1Himachal institute of pharmaceutical education and research, nadaun , H.P (India).
2Department of qulaity assurance in industry, baddi, H.P. (India)

ABSTRACT

The study was undertaken with an aim to formulate develop and evaluation of Aceclofenac sustained release tablets using different polymers(hpmc, carbomer) as release retarding agent. Preformulation study of Aceclofenac was done initially and results directed for the further course of formulation. Based on preformulation studies different batches were prepared using selected excipeints. Granules were evaluated for tests LOD, Bulk density, tapped density, compressibility index, Hausner ratio before being punched as tablets. Tablets were tested for weight variation, thickness, hardness and friability as per official procedure. Dissolution of batch T-8 was carried out in 6.8 pH media and compared with marketed preparation. Based on dissolution tests and F-2 values in pH 6.8 phosphate buffer as release medium, it was concluded that T-8 satisfactory performs in the same manner as that of marketed formulation. F-2 (similarity factor) value of T-6 was found to be 73.90.

Keywords: Aceclofenac, Granules, Weight variation, Hardness.


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