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Abstract

A STUDY TO COMPARE THE HEPATOPROTECTIVE ROLE OF NIGELLA SATIVA AQUEOUS SOLUTION AND OIL SUSPENSION FOLLOWING ACETAMINOPHEN INDUCED HEPATOTOXICITY IN LAYER CHICKS

Ruqaiya Hasan*, Taseer A. Khan, Muhammad N. Khan, and Aiman Kanwal

ABSTRACT

This investigation is performed to compare the reported
hepatoprotective activity of Nigella sativa (Black Seed) aqueous
solution and oil suspension by measuring the mean serum Aspartate
transaminase (AST) and Alanine transaminase (ALT) levels following
the administration of single toxic dose of 300 mg acetaminophen / kg
body weight in Layer chicks. Blood samples drawn after 72 hours of
drug administration showed a non significant rise of AST and ALT in
the chickens treated with Nigella sativa aqueous solution and unaltered
levels of serum AST and non significant high levels of ALT in the
chickens treated with Nigella sativa oil suspension for 15 days, in
comparison to controls. Thus it is concluded that Nigella sativa oil
effectively provides hepatoprotection against toxic agents due to its active ingredient
thymoquinone with antioxidant property, and there is a need to explore the minimum
effective dose of Nigella sativa oil.

Keywords: Hepatoprotection, Layer chickens, Lliver enzymes, Nigella sativa


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