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Abstract

FORMULATION, CHARACTERIZATION AND EVALUATION STUDIES ON MICROSPHERES OF AMLODIPINE

Pankaj Kumar1, Kalpna Kanwar2, Pankaj Bhateja3, Surya Prakash Gautam3, Sunita3, Archana3

1Department of Qulaity Assurance in Industry, Baddi, H.P.
2Shoolini Institute of Biotechnology, Solan, H.P.
3Himachal Institute of Pharmaceutical Education And Research, Nadaun, H.P. INDIA.

ABSTRACT

The study was under taken with an aim of formulation characterization and Evalution of Amlodipine microspheres using Ethyl cellulose polymer. Preformulation study was done on pure drug. And results directed for further course of formulation. Based on preformulation studies different batches of Amlodipine microspheres formulated by using selected polymer. Spheres were evaluated for bulk density, tapped density, compressibility index and angle of repose . Dissolution of batch F1, F2, F3 was carried out in PH 6.8 phosphate buffer medias. Based an dissolution tests, it was concluded that F3 statisfactory release in 24 hours. From the above results and disscussion it is concluded that formulation of control release spheres of Amlodipine containing Ethylcellulose (1:9Ratio). F3 can be taken as an ideal or Optimized formulation of control release for 24 hours release as it ful fills all the requirements for sustained release.

Keywords: Amlodipine, Preformulation, Dissolution, Ethyl cellulose, Sustained Release.


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