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Abstract

EFFECT OF BREYNIA RHAMNOIDES LEAVES EXTRACTION HIGH FRUCTOSE DIET INDUCED C57BL/6J OB/OB DIABETIC MICE

Amaranth V. Banagar, B. Shivakumar* and K.N. Jayaveera

ABSTRACT

The objective of the present study was to investigate anti-diabetic and nephroprotective and cardioprotective activity of Breynia rhamnoides leaves extract, using High Fructose induced diabetic C57BL/6Job/ob mice as model for clinical type-2 diabetic. At a regular interval of experimental protocol blood glucose, urinary creatinine, total proteins, insulin resistance, total β-cell count, LDL, HDL, VLDL, and organs to body weight ratio were studied. The histo-pathological study was carried out by High Fructose induced diabetic and anti-diabetic rats pancreas. Statistical analysis of the results shown that in High Fructose induced diabetic rats chloroform and alcohol extracts of Breynia rhamnoides leaves at 40, 80, 160 and 200 mg/kg doses. Breynia rhamnoides leaves extract improved renal creatinine clearance, decreased the LDL, VLDL, increased the HDL and reduce renal total protein loss demonstrating nephroprotective and cardioprotective properties. The organ to body weight ratio studies carried out on last day, shown pancreas and liver specific effects of Breynia rhamnoides leaves, these results were also supported by histo-pathological studies. We conclude from the present study that Breynia rhamnoides alcoholic extract and Breynia rhamnoides chloroform extract long-term treatment may be beneficial in the management of diabetes.

Keywords: Breynia rhamnoides (BRR), high fructose diet, antihyperglycemic, C57BL/6Job/ob mice.


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