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Abstract

COMPARATIVE EVALUATION OF IN-VITRO ANTI-OXIDATIVE AND ANTI-DIABETIC PROPERTIES OF HYDROETHANOLIC EXTRACTS OF PITHECELLOBIUM DULCE AND PROSOPIS CINERARIA LEAF AND FLOWER

Swaati Sharma, Nitika Verma, *Veena Garg and Nidhi Sharma

ABSTRACT

In Diabetes Mellitus (DM), elevated level of post prandial hyperglycemia (PPHG) is a major risk factor and its reduction can manage DM. Therapeutic approach of antidiabetic activity is to minimize the production of gastrointestinal glucose and inhibition of carbohydrate digesting α-amylase and α-glucosidase enzymes to control PPHG associated with diabetes. In this study the antidiabetic activity of α – amylase and α – glucosidase enzyme was found to be inhibitory in the leaf and flower extracts of Pithecellobium dulce and Prosopis cineraria. Antioxidants are helpful in maintaining cellular and systemic health and hence, effectively manage stress developed during diabetes. To determine anti-oxidative activity of the plants, Numerous enzymatic and non-enzymatic parameters like, superoxide dismutase (SOD), catalase (CAT), peroxidase, DPPH, hydroxyl radical scavenching assay and metal chelating activity were tested. Both the plants showed significant potential to manage invitro antidiabetic activities but out of the four extracts, the leaf extract of P. dulce showed highest significant inhibitory effect. Moreover, enzyme inhibition was increased with increasing concentration of the extracts. These plants also showed good invitro antioxidant activities. All the studied parameters of antioxidant activities in P. dulce and P.cineraria, significantly increased with increasing concentration of plant extract.

Keywords: In-vitro Antidiabetic, In-vitro Antioxidative, IC50, Pithecellobium dulce, Prosopis cinereria and 50% hydroethanolic extract.


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