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Abstract

HEMATINIC ACTIVITY OF HERBO MINERAL DRUG AYAVEERA CHENDURAM (AVC) IN SWISS ALBINO RATS

D. Sangeetha *, M. Mohamed Musthafa, G.Sekar

ABSTRACT

Anemia is a serious public health challenge in India and has devastating effect on health physical and mental productivity affecting the quality of life. Ayaveera chenduram, a traditional Siddha herbo mineral formulation has been employed to treat anemia as per SR pharmacopeia. The present study has been carried out to access the hematinic activity of AVC on invivo rat models after the toxicological study (as per OECD guidelines 423 & 407) and proven safety up to 400mgs/kg p.o. The clinical trial has been approved by IEC [IEC NO: GSMC-CH/1/2013/014] and preclinical by IAEC [IAEC XXXIX/10/CLBMCP/2013 Dated 29.06.2013]. The hematinic activity was conducted in swiss albino rats by single intra peritoneal injection of phenyl hydrazine at a dose of 20mg/kg b.w. Drug treatment was carried out for 14 days at 2 dose level 200mg/kg p.o and 400mg/kg p.o. the trial drug was found to increase The hemoglobin count (Hb), Red blood count (RBC), packed cell volume (PCV), Mean corpuscular volume (MCV), Mean corpuscular hemoglobin (MCH) significantly (P <0.05).

Keywords: Anemia, Ayaveera Chenduram, Hematinic activity, preclinical study.


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