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Abstract

FORMULATION AND EVALUATION OF COLON TARGETTED PULSE IN CAP SYSTEMS OF THEOPHYLLINE FOR NOCTURNAL ASTHMA

Pasam jyothirmayi* B.sivaranjani

ABSTRACT

Asthma may be the most common disease with the largest circadian
variation. Nocturnal asthma is currently controlled by taking either a
long-acting β2 agonists like salmetrol inhalers, or bronchodilator such
as sustained release Theophylline. The oral route is considered to be
most convenient for the administration of drugs to patients. But it has a
serious drawback in conditions where localized delivery of the drug in
the colon is required. The objective of the present study was to develop
and evaluate an oral pulsatile drug delivery system for asthma by
releasing the drug with a distinct predetermined lag time of 5 hrs to
prolong the release and for colon targeting of TPH to treat the nocturnal symptoms of asthma.
If the formulation is administered in the night at 10.00 pm symptoms that are experienced in
early morning hours could be avoided. In the present study, polymers such as hydroxyl
propyl methyl cellulose and Xanthan gum selected for colon targeting of TPH. TPH granules
were prepared by wet granulation and polymer plugs were prepared by using polymers
hydroxyl propyl methyl cellulose and xanthane gum to prolong the release and target to the
colon. These granules filled into the formaldehyde treated capsules and plugged with
optimized polymer plug to maintain the 5hr lag time. Finally capsules are enteric coated with
enteric coating polymers and conducted dissolution studies.

Keywords: Asthma, Pulsatile drug delivery system of theophylline, Chrono-biological action, Pulse in cap systems, colon targeted drug delivery.


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