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Abstract

EFFECT OF GENDER ON DYSLIPIDAEMIA IN PATIENTS OF TYPE II DIABETES MELLITUS

Vinu Vij*, Pallavi Chitnis, Vijay Kumar Gupta.

Department of Physiology, Pad.Dr D Y Patil Medical College and Hospital, Nerul, Navi Mumbai, India.

ABSTRACT

Type II diabetic patients are at an increased risk of coronary artery disease and cerebrovascular disease because of deranged lipid metabolism. The objective of the present study was to determine effects of gender on dyslipidaemia in type II diabetic patients. Pattern of dyslipidaemia in a total of 100 type II diabetic patients (50 males and 50 females) was studied and compared by measuring all the four lipid profile parameters - total cholesterol (TC), triglycerides (TG), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C). Glycosylated haemoglobin (HbA1c) and fasting plasma glucose (FPG) was also measured and the mean value was found to be higher in females in comparison to the male patients and the differences were significant(P<0.05). Among the circulating lipids, total cholesterol (TC), triglycerides (TG) and low density lipoproteincholesterol (LDL-C) were significantly higher (P<0.05) in female patients. Although the mean level of high density lipoprotein-cholesterol (HDL-C) was slightly higher in females than males and this difference was also statistically significant, still the protection conferred by HDL-C on females is questionable in the given setting. Thus, type II diabetic females have a more adverse atherogenic profile as compared to males. An early intervention to normalize circulating lipids has been shown to reduce cardiovascular complications and mortality.

Keywords: Type II diabetes mellitus, dyslipidaemia, gender.


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