WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

PREPARATION AND CHARACTERISATION OF CAPECITABINE LOADED PLGA NANOPARTICLES FOR COLORECTAL CANCER

Prasanna S.Sutar*, Vijaya G. Joshi, Kishori P. Sutar, Kishore G.Bhat

ABSTRACT

The main goal of the present investigation was to formulate and evaluate Capecitabine loaded PLGA nanoparticles for colon cancer treatment. Nanoparticles of Capecitabine were prepared by Emulsion droplet coalescence method using PLGA 50-50 as the polymer. The nanoparticles obtained were evaluated for morphology, loading efficiency, in vitro release study. C2 formulation showed drug release of 66.14 at 24 hours with smaller particle size of 141.66 ± 10.23 and 61% drug loading. Concentration of PLGA 50-50 and drug release was proportionate to each other. DSC and FTIR studies showed that the drug and polymers were compatible with each other and did not reveal any signs of interactions. SEM image of optimized formulation C2 showed spherical and smooth surfaced particles. Biological evaluation was carried by using HT29 (Human colorectal Adenocarcinoma) cell lines and formulation C2 showed 60% cell lysis. This drug delivery targeted the colon cancer cells and provided a better therapy to the patient by reducing toxicity to the normal cells. Kinetic study indicated that the formulations followed first order kinetics.

Keywords: Nanoparticles, Capecitabine, Colorectal cancer, PLGA.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More