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Abstract

HPMCK4M AND GUM KARAYA: INFLUENCE ON RELEASE MECHANISM OF CARVEDILOL PHOSPHATE FROM BUCCOADHESIVE TABLETS

Gopa Roy Biswas*, Sutapa Biswas Majee, Soumendra Mohan Saha

ABSTRACT

Drug release mechanism from matrix dosage form is governed by polymer swelling, polymer erosion, drug dissolution/diffusion, drug distribution inside the matrix and drug/polymer ratio. Thus for the preparation of controlled release dosage form , hydrophilic , swellable, porous polymeric material alone or in optimum combination is essential. Here a plant derived polymer like Gum karaya (GK) and HPMCK4M have been selected to prepare buccal tablets to study the buccoadhesive strength and the release kinetics of Carvedilol phosphate. Three different ratios of HPMCK4M and Gum karaya have been considered to prepare buccoadhesive tablets. Their physicochemical tests revealed satisfactory results. Buccoadhesive strength was found to be in the range of 32-36 gm, which is good enough to hold the buccal tablets inside the buccal cavity. Percent Swelling of the buccoadhesive tablets were in the range of 47.11-53.09. Swelling is maximum in the tablet where GK and HPMCK4M ratio is 1:1. Drug dissolution from buccoadhesive tablets has been described by kinetic models. The release data were fitted in different kinetic models. like zero order, first order and Higuchi . Buccoadhesive tablets incorporating HPMCK4M and GK at 5:7 and at 1:1 provided zeroorder release over 8 hours. A combination of HPMCK4M with GK at 7:5 reveals the dominance of the high viscosity gel formed by HPMC and hence drug release obeyed mixed kinetics.

Keywords: Gum karaya, HPMCK4M, Buccoadhesion, Release kinetics.


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