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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR CHLORTHALIDONE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

*Sapana U. Ingle, Pallavi A. Patil, Vaishali C. Kulkarni, Sheetal V. Patil,Poonam A. Salunke, Rupali S. Wagh.

ABSTRACT

A new, simple, accurate, rapid and precise spectrophotometric method has been developed for validation of chlorthalidone (CTD) in bulk drug. An attempt was made to preclude the use of corrosive inorganic solvents by the use of 0.2 M NaOH. The developed method was the measurement of absorptivity at 274.5nm (absorption maximum of CTD). The results of analysis have been validated as per ICH guidelines. The Concentrations of this drug were evaluated in laboratory mixture and marketed formulation. Accuracy was determined by recovery studies from marketed formulation and Ranges From 97.87-107.39%. Precision of method was find out as repeatability shows the values within acceptable limit.

Keywords: chlorthalidone, UV Spectrophotometric method development, validation.


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