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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR NEBIVOLOL HYDROCHLORIDE IN BULK DRUG USING MIXED HYDROTROPIC SOLUBILISATION

*Pallavi A. Patil, Sapana U.Ingle, Vaishali C. Kulkarni, Sheetal V. Patil,Poonam A. Salunke, Rupali S. Wagh

ABSTRACT

An analytical method for the validation of NEBIVOLOL HYDROCHLORIDE by UV spectrophotometry using hydrotropic solubilization is described. An attempt was made to preclude the use of corrosive organic solvents by the use of 6M Urea, 25% citric acid & 1% Sodium lauryl sulphate (SLS). The developed method has the measurement of absorptivity at 282 nm (absorption maximum of Nebivolol HCL). The method is simple, fast and accurate and has been applied successfully for the validation of Nebivolol HCL in pharmaceutical dosage forms. Accuracy was determined by recovery studies from marketed formulation and Ranges From 99.22 – 100.07 %. Precision of method was find out as repeatability, Day To Day and Analyst To Analyst variation and shows the values within acceptable limit.

Keywords: Nebivolol, Mixed hydrotropy, UV spectrophotometric method, Validation.


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