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Abstract

ANALYTICAL METHODS FOR THE DETERMINATION OF GLICLAZIDE IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL FLUIDS

*Vipin Kumar Sharma, Bhaskar Mazumder

ABSTRACT

Diabetes/ Diabetes mellitus, a group of metabolic diseases is identified in patients with high blood sugar, either because the pancreatic cells does not produce enough insulin, or the body cells do not respond to the insulin that is produced. It is categorized on the response of body cells towards insulin and known as insulin dependent diabetes mellitus (IDDM, Type I) and non insulin dependent diabetes mellitus (NIDDM Type II). Numbers of drugs are used for the management of both types of diabetes and amongst the types of drugs, sulphonyl urea have their own significant. These agents stimulate the pancreatic cells to increase the insulin secretion. Gliclazide, a category II sulphonyl urea is used in the management of NIDDM. In contrast with other sulphonyl urea, gliclazide is a highly efficient drug and a specific dose is required in the management of high blood glucose level in diabetes. The variability in absorption pattern in inter- and intra-patient creates the bioavailability problems during oral administration of gliclazide. Hitherto, various analytical techniques have been developed for the quantification of gliclazide in pharmaceutical dosage forms as well as in biological fluids. This study is based on the overview of different instrumental techniques with their characteristics for quantification of gliclazide.

Keywords: bioavailability, diabetes mellitus, sulphonyl urea, high performance liquid chromatography.


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