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Abstract

LIPID PEROXIDATIVE DAMAGE AND ALTERATIONS IN ANTIOXIDANT STATUS IN RAT ERYTHROCYTES ON REPEATED EXPOSURE OF ?-CYHALOTHRIN AND FLUORIDE ALONE AND IN COMBINATION

Imtiyaz Ahmad, Rajinder Raina*, Pawan Kumar Verma, Mahrukh Ahmad, M Sultana

ABSTRACT

Accidental exposure or injudicious application of pesticides and toxic metals cause adverse health consequence in non-target species including human and animals. The present study was aimed to investigate the lipid peroxidative damage and alterations in antioxidant status in rat erythrocytes on repeated exposure of λ-cyhalothrin (LCT) and fluoride (F) alone and in combination. Forty two wistar were divided into seven groups with six rats in each. Group I without treatment served as control. Group II and III were provided drinking water containing F at the rate of 1 and 10 ppm, whereas rats of Group IV and V were administered LCT at the dose rate of 2 and 10 mg/kg through oral gavage respectively. The animals of group VI and VII received both toxicants daily for 28 days. Repeated exposure of either LCT or F produced significant (p<0.05) reduction in activities of superoxide dismutase, catalase, glutathione peroxidase in erythrocyte membrane and blood glutathione level in rats as compared to control. Concurrent exposure of both the toxicants produces more pronounced effects as indicated by increased lipid peroxidative damage and decreased antioxidant status in wistar rats as compared to control and alone exposed toxicants. Observations suggests that use of LCT in areas having high fluoride content in ground water should be restricted to minimize subtle effect in non-target species.

Keywords: ?-cyhalothrin; Fluoride; Antioxidant parameters; Free radicals.


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