DEVELOPMENT AND EVALUATION OF FLOATING DICLOFENAC SODIUM-ALGINATE BEAD USING BIOPOLYMER OBTAINED FROM VIGNA RADITA
Rajni Karakoti*, Vikas Bhatt, Arun Kumar Singh, Dr. Dinesh Kumar Sharma
ABSTRACT
The aim of present investigation was to isolate, characterize the
biopolymer obtained from Vigna radiata, belonging to the family
fabaceae and their use in development of dosages form. The
biomaterial was isolated from Vigna radiata by non solvent addition
method and characterise its physicochemical and phytochemical
properties. Diclofenac Sodium is used as model drug for the
development of biopolymer-alginate beads. Five bathes (A1-A5) of
Diclofenac sodium biopolymeric-alginate bead were prepared from
sodium alginate solution containing Vigna radiata (a novel
biopolymer) by using ionic gelation method. The different
concentration of sodium alginate, biopolymer and cross linking agent
CaCl2 were used.Formulated beads were evaluated for their entrapment efficiency, drug
loading efficiency, buoyancy test, in-vitro release, size & shape. Drug entrapment efficiency
was found better by using optimized concentration of CaCl2 and biopolymer. Results of the
present study indicates that formation of completely aqueous enviornment avoiding the use of
organic solvents to minimize the curing time of beads leaded to enhanced drug entrapment
efficiency and the biopolymer serves as a better alternative excipient for the development of
dosages and their prospective results was found to be in the limit of Pharmacopoeial
standard.
Keywords: Diclofenac sodium, Biopolymer, Vigna radiata , alginate beads, cross linking agent, buoyancy and loading efficiency.
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