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Abstract

DEVELOPMENT AND EVALUATION OF FLOATING DICLOFENAC SODIUM-ALGINATE BEAD USING BIOPOLYMER OBTAINED FROM VIGNA RADITA

Rajni Karakoti*, Vikas Bhatt, Arun Kumar Singh, Dr. Dinesh Kumar Sharma

ABSTRACT

The aim of present investigation was to isolate, characterize the biopolymer obtained from Vigna radiata, belonging to the family fabaceae and their use in development of dosages form. The biomaterial was isolated from Vigna radiata by non solvent addition method and characterise its physicochemical and phytochemical properties. Diclofenac Sodium is used as model drug for the development of biopolymer-alginate beads. Five bathes (A1-A5) of Diclofenac sodium biopolymeric-alginate bead were prepared from sodium alginate solution containing Vigna radiata (a novel biopolymer) by using ionic gelation method. The different concentration of sodium alginate, biopolymer and cross linking agent CaCl2 were used.Formulated beads were evaluated for their entrapment efficiency, drug loading efficiency, buoyancy test, in-vitro release, size & shape. Drug entrapment efficiency was found better by using optimized concentration of CaCl2 and biopolymer. Results of the present study indicates that formation of completely aqueous enviornment avoiding the use of organic solvents to minimize the curing time of beads leaded to enhanced drug entrapment efficiency and the biopolymer serves as a better alternative excipient for the development of dosages and their prospective results was found to be in the limit of Pharmacopoeial standard.

Keywords: Diclofenac sodium, Biopolymer, Vigna radiata , alginate beads, cross linking agent, buoyancy and loading efficiency.


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