WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF PARACETAMOL, GUAIFENESIN, AMBROXOL HYDROCHLORIDE, PHENYLEPHRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE IN BULK AND COMBINED DOSAGE FORM

Sravya Neeli*, Shanta Kumari Katakam

ABSTRACT

An RP-HPLC method for the simultaneous determination of Paracetamol, Guaifenesin, Ambroxol hydrochloride, Phenylephrine hydrochloride and Chlorpheniramine maleate in tablets was developed and validated ® as per ICH and FDA guidelines. The method was carried out on a with Zodiac C18 (50mm x 4.6mm, 5μm) column. Ortho phosphoric acid buffer (1M) and Acetonitrile in the ratio (50:50v/v) used as mobile phase and flow rate of 1.5ml/min. The detection was carried out at 225nm and ambient column temperature was maintained. The linearity of the proposed method was investigated in the range 10-75μg/mL (r2= 0.999) for Phenylephrine, 200-1500 μg/mL (r2= 0.999) for Paracetamol, 20-150μg/mL (r2= 0.999) for Guaifenesin, 6-45μg/mL (r2=0.999) for Ambroxol, and 4-30μg/mL (r2=0.999) for Chlorpheniramine. The amount of both drugs estimated by the proposed method was found to be in good agreement with labelled claim. The developed method was validated for precision, accuracy, sensitivity, robustness and ruggedness. The developed method can be used for routine analysis of titled drugs in combined dosage form.

Keywords: Paracetamol, Guaifenesin, Ambroxol hydrochloride, Phenylephrine hydrochloride, Chlorpheniramine maleate, RP-HPLC, Validation, Zodiac C18 column.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More