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Abstract

HEPATOPROTECTIVE ACTIVITY OF HERBAL FORMULATION IN PARACETAMOL INDUCED TOXICITY IN ALBINO RATS

Yuvarani . S, Radhika. J*, Jothi. G, Sangeetha. D

ABSTRACT

Hepatotoxicity is an injury to the liver that is associated with impaired liver function caused by exposure to a drug or various other agents. The present study was carried out to evaluate the hepatoprotective activity of a formulation comprising of Atrocarpus heterophyllus LamCurcuma amada Roxb and Piper longum Linn in wistar albino rats. The animals were divided in to six groups comprising of six rats each. Hepato toxicity was induced using paracetamol at a dose of 2g/kg bw orally as a single dose. Group 1 served as normal control. Group II was induced with paracetamol at a dose of 2g/kg bw orally as a single dose. Group III was induced with paracetamol and administered the formulation at a dose of 100mg/kg bw for 15 days orally. Group IV was induced with paracetamol and administered the formulation at a dose of 200mg/kg bw for 15 days orally. Group V was induced with paracetamol and administered Liv – 52 at a dose of 1ml/kg 3 times a day for 15 days. Group VI received formulation alone at a dose of 200/kg bw for 15 days. Serum enzyme markers Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), Gamma Glutamyl Transferase (GGT) were measured. Further that serum bilirubin, liver glycogen, membrane bound Na+ K+ - ATPase and lipid profile in both serum and tissue were analysed. Histopathology of liver tissue was performed. The results obtained were statistically significant (p<0.05) and were in par with that of the Liv – 52 treated group. All the biochemical changes observed in the hepatotoxicity induced rats were reversed in a dose dependent manner. The results obtained clearly depict the hepatoprotective potentials of the formulation.

Keywords: Hepatoprotective, Na+ K+ ATPase, Atrocarpus heterophyllus, Curcuma amada, Piper longum, Paracetamol.


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