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Abstract

UV SPECTROSCOPIC METHOD DEVELOPMENT AND VALIDATION OF ALLOPURINOL IN BULK AND PHARMACEUTICAL DOSAGE FORM

Srujani. Ch*, Anushakanthi. M, Varanasi. S.N. Murthy

ABSTRACT

Allopurinol, 1H-pyrazolo [3,4-d]pyrimidin-4(2H)-one is a drug used primarily to treat hyperuricemia and its complications, including chronic gout. A simple, rapid, accurate, specific and highly sensitive UV spectroscopic methods were developed and validated for the estimation of Allopurinol in bulk and pharmaceutical dosage form. The absorption maxima was found to be 250.6nm for the method A(Zero order), 238nm for method B(first order derivative) and for method C(Area under curve) was measured from 245-255nm. The solvent used was methanol for the preparation of stock solution and distilled water was used for the further dilutions. The methods were found to be linear in the range of 5-35μg/ml and the correlation coefficient values were found to be 0.999, 0.999, 0.9985 respectively. The developed methods were validated in terms of linearity, accuracy, precision in accordance with the ICH guidelines. The proposed methods can be used for the estimation of Allopurinol in bulk and Pharmaceutical dosage forms.

Keywords: Allopurinol, Area under curve, First order derivative spectroscopy, Validation.


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