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Abstract

PROTECTIVE EFFECT OF MOMORDICA CHARANTIA EXTRACT ON LEAD-INDUCED MALE REPRODUCTIVE TOXICITY IN RATS

M. M. Abarshi*, S. B. Mada, A. Garba, and H. A. Mohammed

ABSTRACT

Infertility is a reproductive health problem worldwide that affects many couples especially in developing countries. The present study aimed to investigate the protective effects of Momordica charantia extracts (MCE) on lead-induced male reproductive toxicity. Thirty male rats were randomly divided into five groups of six rats each. The rats were treated daily for 28 days. The phytochemical analyses showed that the plant possess polyphenols, flavonoids, alkaloids, saponins and tannins. The results obtained revealed that pretreatment of rats with MCE significantly (P<0.05) attenuated the decrease in body weight compared to untreated group. There was significant (P <0.05) increase in testicular MDA and significant (P <0.05) decrease in GSH levels in lead exposed rats when compared to the control group. However, oral administration of MCE significantly reduced MDA Level and caused significant increase GSH level in a dose dependent manner when compared with untreated group. Similarly, lead exposure caused significant (P <0.05) decrease in sperm count, sperm motility, sperm viability and testosterone level compared to the control group. Oral administration of MCE caused significant (P <0.05) increase in these sperm parameters and testosterone when compared with the control group. Thus, based on the results obtained from the present study, it was found that MCE possess protective effect against lead induced male reproductive toxicity.

Keywords: Lead poison, sperm parameters, protective effect, testosterone, Momordica charantia.


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