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Abstract

POMEGRANATE JUICE ATTENUATES ELEVATION OF ASYMMETRIC DIMETHYLARGININE IN INDOMETHACIN INDUCED PEPTIC ULCER

Jihan Hussein*, Yasmin Abdel Latif, Dalia Medhat, Eman Refaat, Islam El Nahrery, and Abdel Razik Farrag

ABSTRACT

Pomegranate (Punica granatum L.) is a well-known table fruit of tropical and subtropical regions of the world. In this study, we aimed to identify the effect of pomegranate juice ( PJ) on gastric ulcers induced by Indomethacin in experimental rats and exhibit its powerful antioxidant properties as well as its role in reducing asymmetric dimethylarginine (ADMA) that may affect the production of nitric oxide (NO). Forty male albino rats were used in this study and divided into four groups (ten in each group), classified into control, pomegranate, indomethacin and treated groups. Stomach paraoxonase activity and NO were determined, plasma asymmetric dimethylarginine was estimated by HPLC; separation was achieved on reversed phase column (250 X 4.6 mm C18) with 5 μm particle size. The mobile phase consists of sodium acetate buffer, methanol and tetrahydrofuran (THF), the wavelength of UV detector was set at 254 nm. Stomach paraoxonase activity was significantly increased in treated group compared to indomethacin group, in addition to the elevation of NO concomitant with a reduction of ADMA in treated group compared to indomethacin. Pomegranate juice offered significant protection against indomethacin induced gastric ulcer in the experimental rats. It also reduced ulcer index to 2.16 ± 0.12, showing 69.4 % prevention. The biochemical and pathological results in this study appeared the potential effect of pomegranate juice in attenuating the ulceration induced by indomethacin in rat model.

Keywords: Pomegranate juice, indomethacin, peptic ulcer, ADMA, paraoxonase activity.


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