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Abstract

ANTIULCER EFFECTS OF POLYHERBAL FORMULATION OF LAWSONIA INERMIS AND AZADIRACHTA INDICA

*Sonam Rajwar, Mr. Pankaj Khatri

Department of Pharmacognosy, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur-302025, Rajasthan, India.

ABSTRACT

This Study was planned to investigate the different concentrate gradient formulation of Lawsonia inermis and Azadirachta indica in Naproxen & Histamine induced model. In Naproxen induced model the test formulation of Azadirachta indica & Lawsonia inermis (F1) was significant and reduced the ulcer area to 2.40.12 mm2 which is very near to standard . The test drug in F2 potency also significantly reduced the total ulcer area upto 3.580.11 mm2. The test formulation was found insignificant in F3 and F4. But Formulation F5 had extraverted the ulcer area upto an great extent to 30.410.21 mm2 and is completely insignificant. In Histamine induced ulcer model states that the total ulcerative area in control (no drug ) group was 10.650.06 mm2 whereas in standard (Ranitidine) group it significantly reduced to 2.710.12 mm2. The test formulation of Azadirachta indica & Lawsonia inermis F1, F2 and F3 were significant and reduced the ulcer area to 8.10.12mm2 and 8.860.13 mm2 . Whearas F4 was non significant. But F5 had extraverted the ulcer area upto an great extent to 63.560.24 mm2 and is completely insignificant.

Keywords: Ulcer, Lawsonia inermis, Azadirachta indica, Naproxen, Histamine.


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