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Abstract

PROTECTIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS AND SACCHAROMYCES CEREVISIAE AGAINST MULTI-DRUG RESISTANT SALMONELLA ENTERICA SEROVAR TYPHIMURIUM IN VITRO AND IN VIVO

Safa K. Ibraheem*, Abdulwahid B. Alshaibani, Ali H. Ad'hiah

ABSTRACT

It was aimed to investigate anti-bacterial effects of two probiotics (Lactobacillus acidophilus and Saccharomyces cerevisiae) against MDR isolate of S. Typhimurium in vitro and in vivo by using the mouse as an animal model of the infection. Accordingly, five groups of mice were established. In group I, mice received probiotic for 7 successive days, challenged with S. Typhimurium on day 8, and dissected on days 14 and 21. Group II was similarly treated, but the probiotic continued for 14 days. Group III was given a probiotic only; group IV was challenged with S. Typhimurium, while group V was controls. By using the probiotic filtrates at one-fold, two-fold and three-fold concentration, it was found that the three-fold filtrate recorded the highest inhibition zone for both probiotics (S. cerevisiae and L. acidophilus), which were 25.0 ± 1.0 and 31.0 ± 1.0 mm, respectively. Also, both probiotics were effective in reducing S. Typhimurium colony forming units per plate (CFU/plate) in liver and spleen. In liver, mice in group IV showed a count of 224.4 ± 7.26 CFU/plate, which was significantly higher than any CFU count in groups of L. acidophilus and S. cerevisiae. Group II mice recorded better results than group I mice, and a lowest count was observed at day 21, which was 21.6 ± 627 and 27.8 ± 0121 CFU/plate, respectively for L. acidophilus and S. cerevisiae. The results strongly suggest the anti-Salmonella effects of both probiotics.

Keywords: Lactobacillus acidophilus, Saccharomyces cerevisiae, S. Typhimurium.


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