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Abstract

PREPARATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF NEW AZO LIGAND AND SOME OF IT'S METAL COMPLEXES

Asmaa. A. Al-hassani*, Abbas. H. Al-Khafagy and Abid Allah. M. Ali

ABSTRACT

The present investigation describes the synthesis, characterization and
antibacterial activity of the new azo ligand and its metal complexes.
The new azo compound 1-[(3-Trifluromethylphenyl)azo]-2-naphthol
(TFMAN) was prepared from coupling reaction of
trifluromethylphenyldiazonium chloride with 2-naphthol as coupling
component in a basic medium. The prepared ligand was characterized
by elemental and thermal analyses as well as FT-IR, UV-Vis and GCmass
spectroscopic technique. Metal chelate complexes of this azo
ligand with metal ions Co(II), Ni(II), Cu(II) and Zn(II) were prepared
by reacting (TFMAN) with the metal ions in a molar ratio of (1:2)
(metal:ligand). All of the coordination compounds were identified by elemental analysis,
flame atomic absorption, FT-IR, UV-Vis, magnetic susceptibility and conductivity
measurements, in addition to thermal analyses and mass spectra for some of the chelate
complexes. Based on the obtained results the geometry for the complexes was proposed. The
invitro antibacterial activity of the synthesized compounds have been tested against gram
positive and gram negative bacteria. The antibacterial activity assay results showed that
metal complexes posses higher antibacterial activity compared to free ligand.

Keywords: Azo-naphthol, chelate complexes, FT-IR, UV-Vis and GC, mass spectrum, antibacterial activity.


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