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Abstract

FORMULATION AND IN-VITRO EVALUATION OF LANSOPRAZOLE COLON TARGETED DRUG DELIVERY SYSTEM

Ch. Srinivas Reddy*, G. Babu, B. Kusuma Pravallika, R. Suthakaran, B. Naveen

ABSTRACT

Colon targeting is of value for the treatment of diseases of colon such as Gastro esophageal reflux diseases(GERD) and Zollinger- Ellison syndrome, ulcers of the stomach and duodenum. The present work is a Time dependent formulation named ‘Modified Pulsincap’ that would target release of Lansoprazole in the colon thereby affording relief of GERD and being devoid of unwanted systemic side effects. Bodies of hard gelatin capsules were treated with Formaldehyde keeping the cap portion as such. Lansoprazole loaded pellets were prepared by Extrusion-Spheronization technique. Pellets equivalent to 15mg of drug were filled into treated capsule shells and plugged with polymers Guar gum, HPMC 10K, Sodium CMC, Sodium Alginate and Hydroxy Propylcellulose at concentrations (20mg, 30mg and 40mg). The filled capsules were completely coated with 5% Cellulose Acetate Phthalate to prevent variable gastric emptying. The whole system, thus produced is Modified Pulsincap. All Formulations were assayed to determine drug content. The ability of Pulsincap to provide colon specific drug delivery was assessed by In vitro drug release studies in Buffer pH 1.2 for 2 hrs, pH 7.4 (Simulated Intestinal fluid) for 3 hrs & pH 6.8 (Stimulated Colonic fluid) for 7 hours. The results indicated that with formulations containing 30mg of Guar gum, Sodium CMC, Sodium alginate and 40 mg of Sodium alginate, negligible drug release took place in the small intestinal fluid, but the major portion of the drug was released in the colon. It was therefore concluded that Lansoprazole could be successfully colon targeted by the use of „Modified Pulsincap‟.

Keywords: Colon targeting; Extrusion; Spheronization; Pulsincap, Hydrogel polymer; Gelatin capsules.


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