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Abstract

DEVELOPMENT & VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF MECLIZINE HCL BY ABSORPTION MAXIMA, FIRST ORDER DERIVATIVE AND AUC IN BULK AND ITS TABLET DOSAGE FORM

Masthanamma.Sk*, Nafisa Yasmine, K.Vinay Raju, U.Divya, J. Sindu

ABSTRACT

The present work describes three simple, precise and economical UV methods have been developed for the estimation of Meclizine Hcl in bulk and pharmaceutical dosage form. Method A shown the absorbance maxima at 230 nm, method B area under curve method which involves the calculation of integrated value of absorbance with respect to the wavelength between two selected wavelength 225-235 nm respectively and in the first order derivative spectra showed sharp peak at 259 nm for method C. The developed methods were founded to be linear in the concentration range of 2-20 μg/ml. The developed methods were validated by following the analytical performance parameters suggested by ICH. All the validation parameters were within the acceptable range. As economical solvent is used, these methods were used for routine analysis of Meclizine Hcl in bulk and pharmaceutical formulation.

Keywords: Absorption Maxima, Area under curve, Derivative Spectroscopy, Meclizine Hcl, Meclizine Hcl Tablet Dosage form.


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