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Abstract

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF OLANZAPINE AND FLUOXETINE IN BULK DRUG AND TABLETS BY RP-HPLC METHOD

Harika Bheemavarapu*, Mohammad Arief, Madhukar Akkala,
Tejaswini Akkapanthula

ABSTRACT

A simple, sensitive, precise, accurate, linear, reproducible, simple, economic, ecofriendly and rapid HPLC method as per ICH guidelines has been developed. Reverse phase hplc method has been developed for simultaneous estimation of olanzapine and fluoxetine hydrochloride in bulkdrug and dosage forms. The mobile phase used is 55:45:0.03v/v (0.02M Phosphate buffer: Acetonitrile: Triethylamine) delivered at a flow rate of 1.0ml/min at a wavelength detection at 235 nm. The retention time of olanzapine and fluoxetine were 2.40 min and 5.71min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in bulk and combined dosage forms.

Keywords: Olanzapine, Fluoxetine hydrochloride, RP-HPLC, Validaton.


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