WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

HYPOLIPIDAEMIC AND HEPATOPROTECTIVE ACTIVITY OF GYNURA NEPALENSIS DC FLOWER EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC MICE

*Vijay Nigam1, Dr. Padmaa M. Paarekh2, Sukhwant Singh1, Gaurav Goyanar1, Neeraj Upmanyu3 & Jitendra Banweer1

1Sagar Institute of Research, Technology & Science- Pharmacy (SIRTS-P), Bhopal, 482048, M.P., India
2The Oxford College of Pharmacy, Bangalore, Karnataka, India.
3RKDF College of Pharmacy, Bhopal, MP, India.

ABSTRACT

Objectives: In this study, the hypolipidaemic and hepatoprotective effect of aqueous extract of Gynura nepalensis DC was investigated in streptozotocin induced diabetic mice. Method: The flower extract of Gynura nepalensis DC in doses 100 and 200 mg/kg b.w was administered for 21 days and Triglyceride, Cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosthatase (ALP). Results: Administration of the flower extract of Gynura nepalensis DC (100 and 200 mg/kg) for 21 days resulted in significant reduction in serum cholesterol (P<0.0001), Triglyceride (p<0.0001). In addition to that significant decrease in high density lipoprotein (HDL) (P< 0.0001) whereas significant increase in low density lipoprotein (LDL) (P<0.0001), very low density lipoprotein (VLDL) were observed in diabetic mice, which were normalized after 21 days of flower treatment. In addition to that there was a significant increase in hepatic enzymes Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosthatase (ALP) (P<0.0001) in diabetic mice but after the administration of the flower extract the enzymes levels reduced significantly. Conclusion: The flower extract at both the doses 200mg/kg and 100mg/kg have significant hypolipidaemic and hepatoprotective effect in streptozotocin induced diabetic mice.

Keywords: Diabetes mellitus, Lipoproteins, Hepatic enzyme, Hypolipidaemic effect, Hepatoprotective effect, Gynura nepalensis


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More