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Abstract

EVALUATION OF ANTI-ULCER ACTIVITY OF PLATYCODON GRANDIFLORUM A.DC ON MUCOSAL LESION IN RAT

Pruthviraju Namani*, R. Parthibarajan, R.Suthakaran

ABSTRACT

The study was designed to evaluate the anti-ulcer activity of methanolic extract of Platycodon grandiflorum A.DC plant. The plant material successively extracted with methanol and was subjected for phytochemical screening to identify different phytochemical constituents. LD50 studies for methanolic extract were conducted up to the dose level of 2000 mg/kg by following OECD guidelines No.423. The anti-ulcer activity was tested by Aspirin plus pylorus ligation induced gastric ulcer model in rats and Ethanol induced mucosal damage. Preliminary phytochemical studies revealed the presence of amino acids, flavonoids and tannins, Saponin and steroids in the methanolic extract of Platycodon grandiflorum A.DC. The mortality was observed in animals treated with methanolic extract of Platycodon grandiflorum A.DC at dose of 2000 mg/kg body weight. The administration of extract at doses of 200 mg/kg, 400mg/kg, by oral administration, significantly (p<0.05- 0.01) reduce the ulcer score, ulcer index, free acidity, total acidity and gastric juice volume where as pH was significantly (p<0.05, p<0.01) increased , in the Aspirin plus pylorus ligation induced gastric ulcer model in rats and Ethanol induced mucosal damage. The experimental data demonstrated that methanolic extract of roots of Platycodon grandiflorum A.DC possess remarkable antiulcer activity.

Keywords: Platycodon grandiflorum, anti-ulcer activity, ethanol induced mucosal damage.


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