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Abstract

HEPATOTOXIC EFFECT OF ARTESUNATE, AN ANTIMALARIAL DRUG IN WISTAR ALBINO RATS

Ranjita, Jahas J, Rao SN, Shyamjith Manikkoth*

ABSTRACT

To study the effect of artesunate, the antimalarial drug on liver in Wistar albino rats. Methods: Artesunate was administered at a dose of 36, 72 and 110mg/kg body weight intraperitonially respectively for 14 days in Wistar albino rats. The effect of artesunate on liver was assessed based on biochemical and histopathological analysis. Results: The results disclosed that on artesunate administration at a dose of 110mg/kg body weight for 14 days caused a significant increase (p<0.001) in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and gamma glutamyltransferase in serum. Histopathological analysis showed a pattern of hepatocellular necrosis at the above dose. The levels of superoxide dismutase and catalase in liver homogenate were also decreased significantly (p<0.01) in artesunate administered animals. Conclusions: The present study proves that artesunate has a potential to cause hepatic damage.

Keywords: Artesunate, Liver injury, Wistar albino rats.


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