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Abstract

ONE-POT SYNTHESIS OF POLYHYDROQUINOLINE DERIVATIVE AS ANTIMICROBIAL AGENT

Pravin N. Muli, Santosh S. Chobe, Rahul D. Kamble, Shrikant V. Hese,
Pratima P. Mogle, Bhaskar S. Dawane*

ABSTRACT

Alternative Polyhydroquinoline derivatives were synthesized by using a variety of aldehydes, dimedone, methyl-3-aminobut-2-enoate in the presence of basic catalyst i.e. piperidine in ethanol as a solvent. The present methodology offers several advantages such as excellent yields, simple procedure, short reaction times, mild conditions and the compatibility with various functional groups. The compounds were found to be active as antimicrobial agents.

Keywords: one-pot synthesis, Polyhydroquinoline, dimedone, methyl-3-aminobut-2-enoate.


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