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K. Mounika*, B. Venkateswara Reddy, K. Navaneetha Reddy


The purpose of this research work was to develop and evaluate transdermal patches of Carvedilol employing different ratios of hydrophilic polymers by solvent evaporation technique. The main objective is to avoid first pass effect and to improve bioavailability. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Nine formulations consisting of Hydroxy propyl methyl cellulose k4M, Sodium cmc, xanthan gum, in the ratios 1:1, 1:2, 1:3 were prepared. The prepared TDDS were evaluated for in vitro drug release, moisture absorption, moisture loss and mechanical properties. The patches coded as F1, F2, F3 (HPMCk4m) showed maximum release of 93.54%, 95.42%, 97.54% and F4, F5, F6 (Sodium cmc) showed maximum release of 92.67%, 94.76%, 96.74% and F7, F8, F9 (xanthan gum) showed maximum release of 98.89% ,92.75%, 86.35% within 12 hrs. The formulation F7 emerging to be ideal formulation for Carvedilol. The results followed Korsmeyer-peppas kinetics (R2), and the mechanism of release was either by diffusion or erosion. The stability studies were carried out on the most satisfactory formulations F7 and there was no significant difference in the physicochemical parameters, and in in-vitro drug release profiles.

Keywords: Carvedilol; Solvent evaporation technique; Transdermal patch; Mechanical properties; Korsmeyer-peppas kinetics.

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