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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

FORMULATION DESIGN AND EVALUATION OF DOXYCYCLINE HYCLATE FILM COATED TABLETS

L.Kavya,G.Lakshmana murthy, C.Roosewelt

ABSTRACT

The main purpose of this work is to develop Doxycycline hyclate film
coated tablets are prepared by Direct compression and Dry granulation
methods. In the present work, efforts have been made to develop
doxycycline hyclate film coated tablets using disintegrants and film
formers to mask the hygroscopic nature of the drug. Polymers like
hypromellose and ethyl cellulose as film formers. Preformulation
studies like angle of repose, bulk density, tapped density, porosity,
Carr's index, Hausner's ratio wereperformed. 10 batches were
formulated and evaluated for hardness, friability, weight variation,
drug content, disintegration inâ€Â┬Évitro dissolution and stability studies.
Among the six batches, batch F6 was showing 99.8% drug release and
was found to be stable and considered to be best formulation.

Keywords: polymers, film formers, film coated tablets, doxycycline hyclate tablets.


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