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Abstract

SAFETY EVALUATION OF A HERBAL MIXTURE OF AQUEOUS EXTRACTS OF FICUS RACEMOSA AND AZADIRACHTA INDICA: ASSESSMENT OF SUB-CHRONIC TOXICITY IN RATS

Pearl Andrea Dias, Lathika Shetty and Suchetha Kumari Nalilu*

ABSTRACT

Ficus racemosa has been used in traditional medicine for the treatment
of diabetes, dysentery, diarrhea, bilious affections, menorrhage,
haemoptysis, piles, stomach ache and as a carminative and astringent.
While Azadirachta indica has been used extensively in the
management of jaundice, eczema, cough, vomiting, malaria and
diabetes mellitus. Reports of the safety evaluation of each of these
plants are available in literature. However, toxicity profiling of these
plant extracts when used in combination is lacking. Hence, the aim of
the current study was to assess the sub-chronic toxicity of a 1:1
combination of the aqueous extracts of Ficus racemosa stem bark and
Azadirachta indica leaves. Three groups of female albino Wistar rats
received the herbal mixture orally at dose levels of 100, 200 and 1,000
mg/kg body weight (b. wt.) for 28 consecutive days, respectively. The
study was carried out as per Organization for Economic Cooperation and Development
(OECD) guidelines. Behavioral changes, body and organ weights, hematological and
biochemical parameters were analyzed. No concrete evidences of toxicities attributable to
treatment with the herbal mixture were observed on behavioral pattern and body weight
analysis. Significant reduction in organ weights was observed in the treated groups. Changes
in hematology and blood biochemistry were significant.

Keywords: Sub-chronic toxicity, Ficus racemosa, Azadirachta indica, OECD.


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