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Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF FLOATING BILAYERED TABLETS OF VENLAFAXINE HCL

Jilakara Harikrishna*, Yadagiri Phalguna , Swapna, V V S Narayana Reddy Karri

ABSTRACT

The present study was an attempt to formulate and evaluate the floating bilayered tablets of venlafaxine Hcl. Gastro retentive systems can remain in the gastric region for several hours and hence prolongs the gastric residence time of drugs. The present research work was an attempt to formulate and evaluate gastro retentive floating drug delivery system containing venlafaxine Hcl in the form of tablets using polymers like HPMC K100M, HPMC K15M, HPMC K4M and sodium bicarbonate as gas generating agent. The tablets were prepared by direct compression method. The tablets were evaluated for the pre and post compression parameters such as weight variation, thickness, friability, hardness, drug content, in vitro buoyancy studies, and in Vitro dissolution studies and results were within the limits. The in-vitro dissolution studies were carried out in a USP type-II apparatus in 0.1 N Hcl. Among all the formulations (F1 to F16) prepared, batch F12 was the best formulation which showed buoyancy lag time 6sec and the tablet remained buoyant for 12h.

Keywords: Bilayered Tablets, Venlafaxine Hcl, Direct compression method, Gastric residence time, In vitro buoyancy studies.


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