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Abstract

RETROSPECTIVE ANALYSIS OF ADVERSE DRUG REACTIONS INDUCED BY ANTIBIOTICS IN A TERTIARY CARE CENTRE

Dr. A. Renuka*, Dr. C. Vasanthi, Dr. Darling Chellathai

ABSTRACT

Objective: Adverse drug reaction contributes to a serious problem increasing the morbidity, mortality and health care costs worldwide. This study retrospectively analyses the adverse drug reactions of antibiotics in inpatients of tertiary care centre. Methods: This is a retrospective study which analyzes the ADRs of antibiotics in inpatients of Sri Ramachandra Medical College for a period of 1 year (May 2013 to May 2014). ADR reports was collected from the Pharmacovigilance centre and causality assessment was done using WHO (UMC) Uppsala Monitoring Centre. Data was collected from the ADR forms and case sheets. Results: Total number of adverse drug reactions for a period of one year was 136 and adverse drug reaction due to antibiotics in our hospital was 97 with the female predominance of 60.Majority of the adverse drug reaction was from the surgery and medicine department and most of the reactions involved skin. Quinolones was the leading antibiotic to produce reaction, others were cephalosporins and extended spectrum penicillins and all the reactions were mostly mild and moderate. Conclusion: The awareness and spontaneous reporting and recording of adverse drug reaction of antibiotics and other drugs involves a team work and it is a way of strengthening the regional Pharmacovigilance centre to provide a perfect healthcare system.

Keywords: Morbidity, mortality, hospital.


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