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Abstract

FACTORIAL STUDIES ON FORMULATION DEVELOPMENT OF ACECLOFENAC TABLETS EMPLOYING ? CYCLODEXTRIN AND KOLLIPHOR HS15

K.P.R. Chowdary*, S.Gopinath, C.Uma Maheswara Reddy and S.Umamaheswari

ABSTRACT

Aceclofenac is an effective anti inflammatory and analgesic drug. It belongs to class II under Biopharmaceutical classification system and exhibit low and variable oral bioavailability due to its solubility. It is practically insoluble in water and aqueous fluids and its oral absorption is dissolution rate limited. It needs enhancement in solubility and dissolution rate for improvement of its oral bioavailability and therapeutic efficacy. The objective of the present study is enhance the solubility, dissolution rate and formulation development of aceclofenac tablets with fast dissolution characteristics employing βCD and Kolliphor HS15, a non ionic surfactant. The effects of βCD (factor A) and Kolliphor HS15 (factor B) on the solubility and dissolution rate of aceclofenac were evaluated in a series of 22 factorial experiments. Aceclofenac - βCD-Kolliphor HS15 inclusion complexes were also evaluated for their formulation into tablets with fast dissolution rate characteristics. Kolliphor HS15 has not been investigated earlier for this purpose.

Keywords: Aceclofenac, ? Cyclodextrin, Kolliphor HS15, Solubility, Dissolution Rate, Aceclofenac Tablets, Formulation development.


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