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Abstract

FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF LAMIVUDINE USING OCIMUM BASILICUM SEED MUCILAGE AS SUPERDISINTEGRANT

Dr. M. Sunitha Reddy*, Tangella Srividyalalitha

ABSTRACT

The objective of current study involves the formulation and evaluation
of fast disintegrating tablets of Lamivudine using natural
superdisintegrant obtained from pericarp of Ocimum basilicum seed.
Pre compression properties of tablet blend shows that the blend has
good flow properties. Six formulations were prepared and post
compression properties shows that the formulation F2 was the best
formulation as it disintegrated within 22.79±0.01 seconds, drug release
was 99.4±0.41% at 10minutes. It was subjected to accelerated stability
studies at RH 75% and 400 C for a period of one month. The
formulation was found to be stable.

Keywords: Fast disintegrating tablet, Lamivudine, Natural superdisintegrant, Ocimum basilicum seed mucilage.


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