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Raj Kumar Mishra* Prof. Dr. S.K Prajapati Mr. G.C Soni


Present study is completely focused on the development of nanotechnology based drug delivery system, which not only provide desired action in predetermined testamonials but also show rapid and controlled release as per need. Nowdays we are very much aware of this thing that numerous of drugs are rejected from market every day the basic reason behind it is not this that these drugs are not potent to treat but sometimes they are not well absorved due to low strength of delivery system used ,so in the same concern present investigation is based on the development, evaluation of aceclofenac nanoemulsion. In which we have performed litrature review in which we found that delivery system like nanoparticles Nano gel niosomes proniosomes nanoemulsion nanosponges etc are very much fruitful for the delivery of poorly water soluble drugs which are very poorly absorved in conventional forms and hence low potency is seen First of all pre-formulation study is done in this course all the ingredients are tested for various phenomenon such as oil screening is done, safsol+oleic acid is selected as oil phase, calibration curve is plotted after UVabservation of drug to check out the purity of drug sample ACF after that IR of drug, surfactantand co-surfactant used i.e. ACF, PEG400, TWEEN 80 are done to check out the compatibility among them. As the formulation is based on the oral delivery so solubility profile is done for oils and drug partition coefficient of ACF was found i.e. Pseudo ternary phase diagram are plotted which make backbone for the formulation nanoemulsion using aqueous titration method from phase diagram different concentrations ofoil and surfectantand co-surfactant were selected based on the thermodynamic and dispensability test. Optimized formulation was selected forin vivo studyon the basis of higher drug release, optimum globule size minimum polydispersityvalue, lower viscosity and overall lower significant value of co-surfactant. The difference in t max of nanoemulsion found to be (p<0.07)when compared to API drug suspension whereas difference was in significant when compared with tablet. The difference in Cmax of nanoemulsionwas very significant(p<0.01> when compared with conventional tablet and API drug suspension Bioavailability of nanoemulsion in comparison to the the conventional taletis better and has a relevant increase thus nanoemulsion can be used effectively to improve bioavailability of poorly water soluble drugs.

Keywords: Poorly water soluble, bioavailability, pseudo ternary phase diagram, nanoemulsion.

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